Search | Engineering

订阅投稿

首页工程期刊工程焦点工程成就工程前沿关于我们 English

资源类型

期刊论文 74

年份

2023 1

2022 5

2021 6

2020 5

2019 4

2018 4

2017 10

2016 3

2015 2

2014 2

2013 1

2012 2

2011 2

2010 5

2009 3

2008 5

2007 3

2006 1

2004 2

2003 1

展开︾

关键词

合成生物学 5

合成橡胶 2

生物传感器 2

综合评价 2

2016年熊本地震 1

ALOS-2 PALSAR-2 1

BFT 1

InSAR 1

Preissmann格式 1

RiboJ 1

Vague集 1

WASP模型 1

三维形变反演 1

三角范算子 1

中国 1

主成分综合模型 1

产业趋势 1

产量 1

展开︾

检索范围：

排序：展示方式：

Targeting “undruggable” c-Myc protein by synthetic lethality

Chen Wang, Hui Fang, Jiawei Zhang, Ying Gu

《医学前沿（英文）》 2021年第15卷第4期页码 541-550 doi: 10.1007/s11684-020-0780-y

摘要： Synthetic lethal screening, which exploits the combination of mutations that result in cell death, is a promising method for identifying novel drug targets. This method provides a new avenue for targeting “undruggable” proteins, such as c-Myc. Here, we revisit current methods used to target c-Myc and discuss the important functional nodes related to c-Myc in non-oncogene addicted network, whose inhibition may cause a catastrophe for tumor cell destiny but not for normal cells. We further discuss strategies to identify these functional nodes in the context of synthetic lethality. We review the progress and shortcomings of this research field and look forward to opportunities offered by synthetic lethal screening to treat tumors potently.

关键词： synthetic lethality undruggable transcription factor c-Myc

HTML PDF 收藏

The role of PARP1 in the DNA damage response and its application in tumor therapy

null

《医学前沿（英文）》 2012年第6卷第2期页码 156-164 doi: 10.1007/s11684-012-0197-3

摘要：

Single-strand break repair protein poly(ADP-ribose) polymerase 1 (PARP1) catalyzes the poly(ADP-ribosyl)ation of many key proteins in vivo and thus plays important roles in multiple DNA damage response pathways, rendering it a promising target in cancer therapy. The tumor-suppressor effects of PARP inhibitors have attracted significant interest for development of novel cancer therapies. However, recent evidence indicated that the underlying mechanism of PARP inhibitors in tumor therapy is more complex than previously expected. The present review will focus on recent progress on the role of PARP1 in the DNA damage response and PARP inhibitors in cancer therapy. The emerging resistance of BRCA-deficient tumors to PARP inhibitors is also briefly discussed from the perspective of DNA damage and repair. These recent research advances will inform the selection of patient populations who can benefit from the PARP inhibitor treatment and development of effective drug combination strategies.

关键词： PARP1 synthetic lethality PARP inhibitor DNA repair cancer NHEJ

HTML PDF 收藏

Genome reprogramming for synthetic biology

Kylie Standage-Beier,Xiao Wang

《化学科学与工程前沿（英文）》 2017年第11卷第1期页码 37-45 doi: 10.1007/s11705-017-1618-2

摘要： The ability to go from a digitized DNA sequence to a predictable biological function is central to synthetic biology. Genome engineering tools facilitate rewriting and implementation of engineered DNA sequences. Recent development of new programmable tools to reengineer genomes has spurred myriad advances in synthetic biology. Tools such as clustered regularly interspace short palindromic repeats enable RNA-guided rational redesign of organisms and implementation of synthetic gene systems. New directed evolution methods generate organisms with radically restructured genomes. These restructured organisms have useful new phenotypes for biotechnology, such as bacteriophage resistance and increased genetic stability. Advanced DNA synthesis and assembly methods have also enabled the construction of fully synthetic organisms, such as J. Craig Venter Institute (JCVI)-syn 3.0. Here we summarize the recent advances in programmable genome engineering tools.

关键词： CRISPR genome engineering synthetic biology rational design

HTML PDF 收藏

Renewable synthetic fuel: turning carbon dioxide back into fuel

《能源前沿（英文）》 2022年第16卷第2期页码 145-149 doi: 10.1007/s11708-022-0828-6

HTML PDF 收藏

Water-soluble BODIPY and aza-BODIPY dyes: synthetic progress and applications

Gang FAN,Le YANG,Zhijian CHEN

《化学科学与工程前沿（英文）》 2014年第8卷第4期页码 405-417 doi: 10.1007/s11705-014-1445-7

摘要： In recent years, boron-dipyrromethene (BODIPY) and boron-azadipyrromethene (aza-BODIPY) dyes have attracted considerable multidisciplinary attention due to their diverse applications. By introducing various hydrophilic groups, such as quaternary ammonium, sulfonate or oligo-ethyleneglycol moieties into the BODIPY core, the solubilities of these dyes in aqueous solution can be greatly improved while maintaining their high fluorescence quantum yields. Accordingly, applying these fluorescent dyes in aqueous systems to areas such as chemosensors, biomacromolecule labeling, bio-imaging and photodynamic therapy has been achieved. In this article, the recent progress on the synthesis, optical properties and application of water-soluble BODIPY dyes and aza-BODIPY dyes is reviewed.

关键词： boron-dipyrromethene boron-azadipyrromethene synthetic progress applications

HTML PDF 收藏

Removal efficiencies of natural and synthetic progesterones in hospital wastewater treated by different

《环境科学与工程前沿（英文）》 2022年第16卷第10期 doi: 10.1007/s11783-022-1558-z

摘要：

● The concentrations of 61 progesterones in HWW, PFTE, SBTE were evaluated.

关键词： Progesterones Hospital wastewater Primary filtration treatment effluent Secondary biological treatment effluent Disinfection process

HTML PDF 收藏

SCRaMbLE drive application of synthetic yeast genome

Jin Jin, Yuan Ma, Duo Liu

《化学科学与工程前沿（英文）》 2018年第12卷第4期页码 832-834 doi: 10.1007/s11705-018-1749-0

摘要：

HTML PDF 收藏

Hollow-fiber gas penetration electrodes efficiently produce renewable synthetic fuels

《能源前沿（英文）》 2022年第16卷第5期页码 700-705 doi: 10.1007/s11708-022-0842-8

HTML PDF 收藏

合成橡胶化学及技术进展

武冠英

《中国工程科学》 1999年第1卷第3期页码 79-85

摘要：

文章从合成橡胶的化学基础出发，叙述了合成橡胶工业二十世纪以来的过去、现状，并展望未来。着重讨论了合成化学基础及相应聚合工艺过程的进步这两方面的问题。指出合成橡胶化学基础中活性聚合、可控聚合，包括茂金属催化剂仍为近期的重点；气相聚合工艺将会得到较大的发展；高效聚合釜的研究仍是核心问题；环保问题应更受到重视。

关键词：合成橡胶合成化学活性/控制聚合气相聚合

HTML PDF 收藏

Cell-free systems in the new age of synthetic biology

Fernando Villarreal,Cheemeng Tan

《化学科学与工程前沿（英文）》 2017年第11卷第1期页码 58-65 doi: 10.1007/s11705-017-1610-x

摘要： The advent of synthetic biology has ushered in new applications of cell-free transcription-translation systems. These cell-free systems are reconstituted using cellular proteins, and are amenable to modular control of their composition. Here, we discuss the historical advancement of cell-free systems, as well as their new applications in the rapid design of synthetic genetic circuits and components, directed evolution of biomolecules, diagnosis of infectious diseases, and synthesis of vaccines. Finally, we present our vision on the future direction of cell-free synthetic biology.

关键词： cell-free system application

HTML PDF 收藏

polygeneration system of a combination of the gasified coal gas and the pyrolyzed coal gas to form the synthetic

Kechang XIE, Fan LI

《化学科学与工程前沿（英文）》 2010年第4卷第4期页码 383-384 doi: 10.1007/s11705-010-0526-5

HTML PDF 收藏

Flexural behavior of ECC hollow beams incorporating different synthetic fibers

Ahmmad A. ABBAS, Farid H. ARNA ’OT, Sallal R. ABID, Mustafa ÖZAKÇA

《结构与土木工程前沿（英文）》 2021年第15卷第2期页码 399-411 doi: 10.1007/s11709-021-0701-4

摘要： Twelve ECC beams with three different fiber types, along with four normal concrete beams, were tested in this study to evaluate the influence of cross-sectional hollowing on their flexural performance. The fiber types used were nylon monofilament (NM), low-cost untreated polyvinyl alcohol (PVA), and polypropylene (PP). Three different square hole sizes of 60, 80, and 100 mm with cross-sectional hollowing ratios of 0.16, 0.28, and 0.44, respectively, were adopted for each group of beams in addition to a solid beam. All beams were tested under four-point loading using a displacement-controlled testing machine. The test results showed that ECC beams can mostly withstand higher cracking and ultimate loads compared to their corresponding normal concrete versions. The results also showed that both the ductility and toughness of the ECC beams are higher than those of the normal concrete beams and that the ductility values of the hollow beams with a hole size of 60 mm are higher than those of the corresponding solid beams. Moreover, hollow ECC beams with hole sizes of 60 and 80 mm exhibited a higher ductility than a solid normal concrete beam.

关键词： hollow beam hollowing ratio ECC flexural strength ductility toughness

HTML PDF 收藏

Study on a green synthetic method of TRPPMCl (M= Fe, Mn, Co)

Jing FAN, Yuanbin SHE, Aixin WANG

《化学科学与工程前沿（英文）》 2009年第3卷第2期页码 222-223 doi: 10.1007/s11705-009-0059-y

摘要： A green synthetic method using mixted solvents of di-methyl formamide(DMF) and acids instead of single DMF to synthesize metalloporphyrins(TRPPMCl) from TRPPH and MCl metallization was proposed in this paper. A series of TRPPMCl (M= Fe, Mn, Co) were synthesized through this innovative synthetic method, and these complexes were characterized with various spectroscopic techniques, including IR and UV-Vis spectroscopy. The results showed that the metallization time was markedly reduced from about 10 h to 0.5 h in contrast with the conventional synthetic methods.

关键词： TRPPMCl metalloporphyrins green synthesis acid

HTML PDF 收藏

Thermal and catalytic pyrolysis of a synthetic mixture representative of packaging plastics residue

Simona Colantonio, Lorenzo Cafiero, Doina De Angelis, Nicolò M. Ippolito, Riccardo Tuffi, Stefano Vecchio Ciprioti

《化学科学与工程前沿（英文）》 2020年第14卷第2期页码 288-303 doi: 10.1007/s11705-019-1875-3

摘要： A synthetic mixture of real waste packaging plastics representative of the residue from a material recovery facility (plasmix) was submitted to thermal and catalytic pyrolysis. Preliminary thermogravimetry experiments coupled with Fourier transform infrared spectroscopy were performed to evaluate the effects of the catalysts on the polymers’ degradation temperatures and to determine the main compounds produced during pyrolysis. The thermal and catalytic experiments were conducted at 370°C, 450°C and 650°C using a bench scale reactor. The oil, gas, and char yields were analyzed and the compositions of the reaction products were compared. The primary aim of this study was to understand the effects of zeolitic hydrogen ultra stable zeolite Y (HUSY) and hydrogen zeolite socony mobil-5 (HZSM5) catalysts with high silica content on the pyrolysis process and the products’ quality. Thermogravimetry showed that HUSY significantly reduces the degradation temperature of all the polymers—particularly the polyolefines. HZSM5 had a significant effect on the degradation of polyethylene due to its smaller pore size. Mass balance showed that oil is always the main product of pyrolysis, regardless of the process conditions. However, all pyrolysis runs performed at 370°C were incomplete. The use of either zeolites resulted in a decrease in the heavy oil fraction and the prevention of wax formation. HUSY has the best performance in terms of the total monoaromatic yield (29 wt-% at 450°C), while HZSM5 promoted the production of gases (41 wt-% at 650°C). Plasmix is a potential input material for pyrolysis that is positively affected by the presence of the two tested zeolites. A more effective separation of polyethylene terephthalate during the selection process could lead to higher quality pyrolysis products.

关键词： packaging plastics waste plasmix pyrolysis zeolite catalyst degradation temperature

HTML PDF 收藏

溶液聚合合成橡胶节能技术和节能型橡胶的开发

曹湘洪,张爱民

《中国工程科学》 2001年第3卷第7期页码 59-63

摘要：

总结了燕山石化溶液聚合合成橡胶节能技术和节能型橡胶的开发情况。通过改进催化体系，提高反应速度，提高反应器的生产能力，并在聚合反应器中采用带刮刀的搅拌器，同时改进聚合、凝聚、溶剂回收的部分工艺及设备，燕山石化顺丁橡胶的能耗不断下降，达到世界先进水平。溶液聚合合成橡胶凝聚过程热泵技术的工业化，使生产每吨胶可节约1MPa的低压蒸汽0.72t。橡胶溶液直接脱挥，聚丁二烯橡胶气相聚合工艺技术开发,溶聚丁苯橡胶（SSBR）、中乙烯基聚丁二烯橡胶、苯乙烯-异戊二烯-丁二烯橡胶（SIBR）、苯乙烯-丁二烯热塑性弹性体（SBS）等新型节能型合成橡胶的技术开发也在进行中，其中SSBR、SBS技术已经工业化。

关键词：溶液聚合合成橡胶节能节能型橡胶